Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development, and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical industries around the world.

         

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Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA, and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Position: Research Associate/Sr Research Associate – Protein Purification

Location: Bengaluru, Karnataka

Department: Discovery Biology

Job Description:

Job Purpose: The incumbent will perform protein purification and characterization from various expression systems.

Key Responsibilities: 

  • Innovative and motivated professional with a proven track record in protein chemistry.
  • The person is responsible for the technical support for the downstream process.
  • Will be responsible for day to day operational activities in the downstream platform.
  • Should be well versed in the purification of monoclonal antibodies, recombinant proteins expressed using mammalian, microbial, or Insect cell.
  • execute day to day activities of the downstream processes like CIP for Slurry, CIP for AKTA.

  • Actively involved in the statistical design, execution, analysis, and troubleshooting of the purification process.
  • Should have knowledge of QA related to the protein work.
  • Strong communication and cross-department collaboration skills.
  • Must have hands-on experience on AKTA Explorer, AKTA prime and AKTA PURE instruments
  • Additional knowledge on operation and analysis of HPLC / LCMS   instrument and data would be appreciable.
  • Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
  • Attend training on environment, health, and safety (EHS) measures imparted company.

Technical/Functional Skills:

  • Expertise in routine protein purification with affinity, size exclusion, ion-exchange chromatography using AKTA FPLC systems (Unicorn software).
  • Expertise in protein purification of antibodies, affinity-tagged, secreted proteins as well as “problematic” proteins (low expression, poor solubility, intra-cellular expression, prone to aggregation).
  • Proficiency in protein extraction and solubilization methods, protein refolding and purification via affinity, hydrophobic interaction (HIC), ion exchange (IEX), size exclusion (SEC), and mixed-mode chromatography.
  • Expertise in the routine characterization of proteins including SDS-PAGE, SE-HPLC, and biophysical techniques.
  • Familiarity with mammalian and microbial protein expression is a plus.

Behavioral Skills:

  • Take accountability and ownership for respective job functions maintain data integrity & exhibit good data management skills.
  • Excellent attention to detail, diligent documentation, and efficient communication skills.

Qualification: M.Sc/M.Tech – Lifescience

Experience: 0-3 Years Post Education

Salary: Negotiable

Contact Details:

careers@syngeneintl.com

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